Evaluation of Polyhexamethylene Biguanide (PHMB) as a Disinfectant for Adenovirus

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Evaluation of polyhexamethylene biguanide (PHMB) as a disinfectant for adenovirus.

IMPORTANCE Swimming pools can be a vector for transmission of adenovirus ocular infections. Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools and hot tubs. OBJECTIVE To determine whether PHMB is an effective disinfectant against ocular adenovirus serotypes at a concentration used to disinfect swimming pools and hot tubs. DESIGN In vitro laboratory study. INTERVEN...

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Evaluating a dressing impregnated with polyhexamethylene biguanide

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Benefit of polyhexamethylene biguanide in Fusarium keratitis.

PURPOSE To report a series of 3 patients with soft contact lens-related Fusarium keratitis. Two of them were treated with the antiamoebic polyhexamethylene biguanide 0.02% (PHMB) in combination with antifungal drugs, and 1 patient was treated with PHMB as sole antifungal regimen. METHODS Chart review of 3 patients treated with PHMB in Fusarium keratitis. Two of them were refractory to the com...

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Toxicological assessment of polyhexamethylene biguanide for water treatment

Polyhexamethylene biguanide (PHMB) is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. There are regulatory concerns with regard to its safety in humans for water treatment. We decided to assess the safety of this chemical in Sprag...

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Study of Epigenetic Properties of Poly(HexaMethylene Biguanide) Hydrochloride (PHMB)

Poly(HexaMethylene Biguanide) hydrochloride (PHMB) CAS No. [32289-58-0] is a particularly effective member of the biguanides antiseptic chemical group, and has been in use since the early fifties in numerous applications. It has been proposed that PHMB be classified as a category 3 carcinogen although PHMB is not genotoxic. It has been hypothesized that PHMB may have epigenetic properties effec...

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ژورنال

عنوان ژورنال: JAMA Ophthalmology

سال: 2013

ISSN: 2168-6165

DOI: 10.1001/jamaophthalmol.2013.2498